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Either you have too much appetite (with the usual frustrating weight gain), or you have too little, and lose weight without actually trying to diet. As a result, fibromites often experience weight gains or losses that are somewhat abnormal. What IS normal is that people who suffer from chronic pain tend to suffer from at least some degree of depression as a result of the chronic nature of that pain – and depression often leads to abnormal appetite. Increased appetite is also a side effect of some medications normally prescribed for muscle relaxation - low-dose amitriptyline and cyclobenzaprine.